Studies on the intrathecal humoral immune response in canine distemper encephalitis
Identifieur interne : 001593 ( Main/Exploration ); précédent : 001592; suivant : 001594Studies on the intrathecal humoral immune response in canine distemper encephalitis
Auteurs : M. Vandevelde [Suisse] ; A. Zurbriggen [Suisse] ; A. Steck [Suisse] ; P. Bichsel [Suisse]Source :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1986.
English descriptors
- Teeft :
- Acta neuropathol, Albumin content, Antibody concentrations, Antimyelin, Antimyelin antibodies, Appel, Bichsel, Canine, Canine distemper, Canine distemper virus, Cerebrospinal, Cerebrospinal fluid, Demyelinating, Demyelinating lesions, Demyelination, Distemper, Distemper virus, Encephalomyelitis, Higgins, Immune, Immune response, Inflammatory, Inflammatory demyelination, Inflammatory lesions, Intrathecal, Intrathecal production, Krakowka, Lesion, Myelin, Normal dogs, Spontaneous cases, Vandevelde, Viral.
Abstract
Abstract: Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.
Url:
DOI: 10.1016/0165-5728(86)90073-1
Affiliations:
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The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.</div></front></TEI><affiliations><list><country><li>Suisse</li></country><region><li>Canton de Berne</li></region><settlement><li>Berne</li></settlement></list><tree><country name="Suisse"><region name="Canton de Berne"><name sortKey="Vandevelde, M" sort="Vandevelde, M" uniqKey="Vandevelde M" first="M." last="Vandevelde">M. Vandevelde</name></region><name sortKey="Bichsel, P" sort="Bichsel, P" uniqKey="Bichsel P" first="P." last="Bichsel">P. Bichsel</name><name sortKey="Steck, A" sort="Steck, A" uniqKey="Steck A" first="A." last="Steck">A. Steck</name><name sortKey="Zurbriggen, A" sort="Zurbriggen, A" uniqKey="Zurbriggen A" first="A." last="Zurbriggen">A. Zurbriggen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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